The Castro is a neighborhood in Eureka Valley in San Francisco. The Castro was one of the first gay neighborhoods in the United States. Having transformed from a working-class neighborhood through the 1960s and 1970s, the Castro remains one of the most prominent symbols of lesbian, gay, bisexual, and transgender activism and events in the world. Castro Street was named for José Castro (1808–1860), a Californian leader of Mexican opposition to U.S.